Soft Implantable Optoelectronics for Real-Time, Closed-Loop Control of Organ Functionīio-optoelectronic systems enable closed-loop peripheral neuromodulation to alleviate organ dysfunction.
The resulting epidermal VR systems create many new opportunities where the skin provides a communication and sensory input to the body, as demonstrated in social media/personal engagement, gaming/entertainment and prosthetic control/feedback. We have developed a wireless, battery-free platform of electronic systems and haptic interfaces that softly laminate onto the skin to communicate information via spatio-temporally programmable modes of mechanical vibration.
Demonstrations include their application to human induced pluripotent stem cell-derived cortical spheroids and assembloids. We have developed complaint, shape-matched mesoscale platforms in precisely engineered 3D geometries that gently envelop the spheroids/organoids to establish multifunctional electronic, optoelectronic, thermal, mechanical and biochemical interfaces to these systems for fundamental studies of their behaviors. Three-dimensional (3D), sub-millimeter-scale constructs of neural cells, known as neural spheroids and organoids, are of rapidly growing importance in neuroscience research due to their ability to reproduce complex features of brain architecture, function and organization in vitro. Multifunctional 3D Mesostructures as Neural Interfaces to Cortical Spheroids (Mini-Brains) and Engineered Assembloids.By comparison to conventional, hard-wired monitoring systems, these technologies greatly reduce risks for injuries to the delicate neonatal skin, they eliminate constraints on natural movements of the baby, and they facilitate skin-skin contact and bonding between parent and child.
Skin-like Devices for Wireless Monitoring of Vital Signs in Neonatal Intensive Careīattery-free, 'epidermal' electronics with advanced capabilities in data transfer, in-sensor analytics and bi-nodal function enable wireless, clincal-grade measurement of full vital signs information from fragile neonates.